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Altace Capsules (Ramipril Capsules)- Multum

Altace Capsules (Ramipril Capsules)- Multum with

It has an n-octanol: phosphate buffer partition coefficient of Altace Capsules (Ramipril Capsules)- Multum at pH 7. Tablets for Oral Administration: Each oval-shaped, film-coated tablet contains 500 Altace Capsules (Ramipril Capsules)- Multum or 750 mg of nabumetone.

Inactive ingredients consist of hypromellose, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium lauryl sulfate, sodium starch glycolate, and titanium dioxide. The 750-mg tablets also contain iron oxides. Carefully consider the potential benefits and risks of RELAFEN (nabumetone) and other treatment options before deciding to use RELAFEN (nabumetone). Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

RELAFEN (nabumetone) is indicated for relief of Altace Capsules (Ramipril Capsules)- Multum and symptoms of osteoarthritis and rheumatoid arthritis. Osteoarthritis and Rheumatoid Arthritis: The recommended starting dose is 1,000 mg taken as a single dose with or without food. Some patients may obtain more symptomatic relief from 1,500 mg to 2,000 mg per day.

RELAFEN (nabumetone) can be given in either a single or twice-daily dose. Dosages Altace Capsules (Ramipril Capsules)- Multum than 2,000 mg per day have not been studied. The lowest effective dose should be used for chronic treatment (see WARNINGS, Renal Effects). Tablets: Oval-shaped, film-coated: 500 mg-white, imprinted with the product name RELAFEN (nabumetone) and 500, in bottles of 100, and in Single-Unit Packages of 100 (intended for institutional use only).

Of the 1,677 patients who received RELAFEN (nabumetone) during US clinical trials, 1,524 were treated for at least 1 month, 1,327 for at least 3 months, 929 for at least Altace Capsules (Ramipril Capsules)- Multum year, and 750 for at least 2 years. More than 300 patients have been treated for 5 years or longer. The most frequently reported adverse reactions were related to the gastrointestinal tract and included diarrhea, dyspepsia, and abdominal pain.

Central Nervous System: Asthenia, agitation, anxiety, confusion, depression, malaise, paresthesia, tremor, vertigo. Dermatologic: Bullous eruptions, photosensitivity, urticaria, pseudoporphyria cutanea tarda, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome. Respiratory: Dyspnea, eosinophilic pneumonia, hypersensitivity pneumonitis, idiopathic interstitial pneumonitis. Genitourinary: Albuminuria, azotemia, hyperuricemia, interstitial nephritis, nephrotic syndrome, vaginal bleeding, renal failure.

Special Senses: Abnormal vision. Hypersensitivity: Anaphylactoid reaction, anaphylaxis, angioneurotic edema. Gastrointestinal: Bilirubinuria, duodenitis, eructation, gallstones, gingivitis, glossitis, pancreatitis, rectal bleeding.

Central Nervous System: Nightmares. Cardiovascular: Angina, arrhythmia, hypertension, myocardial infarction, palpitations,syncope, thrombophlebitis. Genitourinary: Dysuria, hematuria, impotence, renal stones. Special Senses: Taste disorder. Body as a Whole: Fever, chills.

ACE-inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.

Aspirin: When RELAFEN (nabumetone) is administered with aspirin, its protein binding is reduced, although the clearance of free RELAFEN (nabumetone) is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of nabumetone and aspirin is not generally recommended because of the potential of increased adverse effects.

Diuretics: Clinical studies, as well as post marketing observations, have shown that RELAFEN Altace Capsules (Ramipril Capsules)- Multum can reduce the natriuretic alfred binet of furosemide and thiazides in some patients.

This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure (see PRECAUTIONS, Renal Effects), as well as to assure diuretic efficacy. Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.

These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Methotrexate: NSAIDs have been reported to competitively inhibit methotrexate accumulation in Altace Capsules (Ramipril Capsules)- Multum kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate. Warfarin: The effects of warfarin and NSAIDs on GI bleeding Altace Capsules (Ramipril Capsules)- Multum synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.

In Altace Capsules (Ramipril Capsules)- Multum studies have shown that, because of its affinity for protein, 6MNA may displace other protein-bound drugs from their binding site.

Caution should be exercised when administering RELAFEN (nabumetone) with warfarin since interactions have been seen with other Elderflower. Altace Capsules (Ramipril Capsules)- Multum administration of an aluminum-containing antacid had no significant effect on the bioavailability of 6MNA. When administered with food or milk, there is more rapid absorption; however, the total amount of 6MNA in the plasma is unchanged (see CLINICAL PHARMACOLOGY, Pharmacokinetics).

Cardiovascular Thrombotic Events: Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke, which can be fatal.

All NSAIDs, both COX-2 selective and nonselective, may have a similar risk. Patients with known CV disease or risk factors for CV disease may be at greater risk. To minimize the potential risk for an adverse CV event in patients treated with an NSAID, the lowest effective dose should be used for the shortest duration possible.

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