Arsenic Trioxide Injection (Trisenox)- Multum

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Contraindications and precautions Contraindicated in patients hygiene personal to drug and in those with asthma, rhinitis, or nasal polyps that is precipitated by aspirin or other NSAIDs.

Use cautiously in elderly patients and those with a history of peptic ulcer disease or renal, CV, GI, or hepatic disease. Acetaminophen, anti-inflammatories, gold compounds: Increases nephrotoxicity. Anticoagulants, thrombolytics, such as coumadin derivatives, heparin, streptokinase, and urokinase: May potentiate anticoagulant effects. Monitor PT and INR. Antihypertensives, diuretics: Decreases effects of these drugs. Using together may increase risk of nephrotoxicity.

Anti-inflammatories, corticosteroids, corticotropin, salicylates: May cause increased GI Arsenic Trioxide Injection (Trisenox)- Multum reactions, including ulceration and hemorrhage.

Use together very cautiously. Aspirin: May decrease the bioavailability of naproxen. Monitor patient for lack of effectiveness.

Aspirin, cefamandole, cefoperazone, dextran, dipyridamole, mezlocillin, parenteral carbenicillin, piperacillin, plicamycin, salicylates, sulfinpyrazone, ticarcillin, valproic acid, other anti-inflammatories: Increases risk of bleeding problems.

Coumadin derivatives, nifedipine, phenytoin, verapamil: Increases risk of toxicity. Insulin, oral antidiabetics: May Arsenic Trioxide Injection (Trisenox)- Multum hypoglycemic effects. Monitor serum glucose level. Lithium, methotrexate: May increase nephrotoxicity. Alcohol use: Increases risk of GI toxicity. Arsenic Trioxide Injection (Trisenox)- Multum reactionsCNS: headache, drowsiness, dizziness, vertigo, confusion.

EENT: visual disturbances, tinnitus, auditory disturbances. GI: epigastric distress, occult blood loss, nausea, peptic ulceration, constipation, dyspepsia, heartburn, diarrhea, stomatitis, thirst. Hematologic: thrombocytopenia, eosinophilia, agranulocytosis, neutropenia, hemolysis. Skin: pruritus, rash, urticaria, health mental counselor, diaphoresis, purpura.

May decrease neutrophil, granulocyte, and platelet counts. Overdose and treatment Signs and symptoms of overdose include drowsiness, heartburn, indigestion, nausea, and vomiting. Administer activated charcoal via nasogastric tube. Provide symptomatic and supportive measures, including respiratory support and correction of fluid and electrolyte imbalances. Monitor laboratory parameters and vital signs closely.

Hemodialysis is ineffective in removing naproxen. Naproxen oral suspension contains 0. Naproxen sodium 220 mg, 275 mg, and 550 mg contain 0. More studies have to be done to make clinical judgments. Watch for Arsenic Trioxide Injection (Trisenox)- Multum and symptoms health occupational fluid retention, especially significant weight gain.



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