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Multiple Electrolytes and Dextrose Injection in AVIVA Plastic Container (Plasma-Lyte 56 and 5% Dextr

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Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. Ontology: Nifedipine (C0028066) Definition (CHV) a drug used for hypertension Definition (NCI) A dihydropyridine calcium channel blocking agent.

Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is Multiple Electrolytes and Dextrose Injection in AVIVA Plastic Container (Plasma-Lyte 56 and 5% Dextr in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

It is a useful anti-anginal agent that also lowers blood pressure. Definition (CSP) calcium channel blocker used as a coronary vasodilator in the treatment of coronary insufficiency and angina. Precautions Pharmacology Indications Contraindications Dosing: Hypertension Dosing: Accutane Labor Adverse Effects Monitoring: When used in Preterm Labor Extra: Related Bing Images Extra: Related Studies Extra: Medication Costs Extra: UMLS Ontology Extra: Navigation Tree About 2021 Family Practice Notebook, LLC.

Gov Survey of pharmacy drug pricing) A dihydropyridine calcium channel blocking agent. It is a significant contributor to cardiovascular events, cardiac death and kidney disease. A number of medication classes exist to aid healthcare providers and their patients in controlling hypertension. Nifedipine, a dihydropyridine calcium channel blocker, was once one of the hsps widely used medications for hypertension, but safety and tolerability concerns along with the introduction of new classes of antihypertensive medications and an increasing pool of data showing mortality benefit of other classes caused nifedipine to fall out of favor.

More kid and teenagers, long-acting formulations were developed and made available to clinicians. These newer formulations were designed to address many of the concerns raised by earlier formulations of nifedipine.

Numerous clinical trials have been conducted comparing long-acting nifedipine to many of the more Somatropin Injection (Norditropin)- FDA prescribed antihypertensive medications. This review will address the pharmacology, pharmacokinetics and the available clinical trial data on long-acting nifedipine and summarize its role in the management of hypertension.

Keywords: nifedipine, calcium channel blockers, hypertension This work is published and licensed by Dove Medical Press Limited. Editorial PoliciesAuthor InformationPeer Review GuidelinesOpen OutlookCOVID-19 Usage 13752 k 23 Days 17 Days 67514 Submit New Manuscript Login to view existing manuscript status Signup for Journal alerts About Dove Press Open access peer-reviewed scientific and medical journals.

Adults: Starting dose is 10 mg P. Usual effective dosage range is 10 to 20 mg t. Some patients may need up to 30 mg q. Or, 30 to 60 mg (extended-release) P. Gradually increased at 7- to 14-day intervals or more frequently, if needed. Maximum dose is 180 mg daily for capsules, 120 mg for extended-release tablets. Adults: Initially, 30 to 60 mg P. Adjust dosage at 7- to 14-day intervals based on patient tolerance and response. Maximum dose is primer roche posay mg daily.

Pharmacodynamics Antianginal action: Nifedipine dilates systemic arteries, resulting in decreased total peripheral resistance and modestly decreased systemic blood pressure with a slightly increased heart rate, decreased afterload, and increased cardiac index.

Reduced afterload and the subsequent decrease in Multiple Electrolytes and Dextrose Injection in AVIVA Plastic Container (Plasma-Lyte 56 and 5% Dextr oxygen consumption probably account for the value of nifedipine in treating chronic stable angina. Metabolism: Metabolized Multiple Electrolytes and Dextrose Injection in AVIVA Plastic Container (Plasma-Lyte 56 and 5% Dextr the liver.

Excretion: Excreted in urine and feces as inactive metabolites. Elimination half-life is 2 to 5 hours. Contraindications and precautions Contraindicated in patients hypersensitive to drug. Use cautiously in elderly patients and patients with heart failure or hypotension. Use extended-release form cautiously in patients with GI narrowing.

Beta blockers: May worsen angina, heart failure, and hypotension. Cimetidine: May decrease nifedipine metabolism. Digoxin: May increase serum digoxin levels. Monitor serum digoxin level. Fentanyl: May cause excessive hypotension. Hypotensive drugs: May precipitate excessive hypotension. Phenytoin: May increase phenytoin levels.

Melatonin: Interferes with antihypertensive effect of nifedipine. Grapefruit juice: Increases bioavailability of drug. Advise patient to avoid taking drug with grapefruit juice.

Adverse reactionsCNS: dizziness, light-headedness, headache, weakness, syncope, nervousness, fever.

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