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Peginterferon Alfa-2b Injection (PegIntron)- Multum

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NAMENDA is administered with a dosing device that comes with the drug and consists of a syringe, syringe adaptor cap, tubing and other supplies a patient needs to administer the drug.

A target dose of 5 mg (2. Manufactured for: Forest Pharmaceuticals, Inc. Subsidiary of Forest Laboratories, LLC St. Manufactured by: Forest Laboratories Ireland Ltd. Therefore, alterations of urine pH towards the alkaline condition may lead to an accumulation of the drug with a possible increase in adverse effects.

Peginterferon Alfa-2b Injection (PegIntron)- Multum pH is altered by diet, drugs (e. Hence, memantine should be used with caution under these conditions. The combined use of NAMENDA with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. See FDA-approved patient labeling (PATIENT INFORMATION and Instructions for Use).

To assure safe and effective use of NAMENDA, the following information and instructions provided in the patient information section should be discussed with patients and caregivers.

They should be made aware of the patient instruction educational that is enclosed with the product. Memantine produced no evidence of genotoxic potential when evaluated in the in vitro S. The results were equivocal in an in vitro gene mutation assay using Chinese hamster V79 cells.

There are no adequate and well-controlled studies of memantine in pregnant women. NAMENDA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Slight maternal toxicity and decreased pup weights were also seen at this dose in a study in which rats were treated from day 15 of gestation through the postpartum period.

Because many drugs are excreted in human milk, caution should be exercised when NAMENDA is administered to a nursing mother.

The efficacy and safety data presented in heart palpitates clinical trial sections were obtained from these patients.

No dosage adjustment is needed in patients with mild or moderate hepatic impairment. The largest known ingestion of memantine worldwide was 2. The patient experienced coma, diplopia, and agitation, but subsequently recovered. Fatal outcome has Peginterferon Alfa-2b Injection (PegIntron)- Multum very rarely reported with memantine, and the relationship to memantine was unclear.

Because strategies for the management of overdose are continually evolving, it is advisable to contact a poison control center to determine the latest recommendations for the management of an overdose of any drug. As in any cases of overdose, general supportive measures should be utilized, and treatment should be symptomatic.

Elimination of memantine can be enhanced by acidification of urine. NAMENDA (memantine hydrochloride) is contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation. Memantine is postulated to exert its therapeutic effect through Peginterferon Alfa-2b Injection (PegIntron)- Multum action as a low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.

Memantine also showed antagonistic effects at the 5HT3 nf2 with a potency similar to that for the NMDA receptor and blocked nicotinic acetylcholine receptors with one-sixth to one-tenth the potency. In vitro studies have shown that memantine does not affect the reversible inhibition of acetylcholinesterase by donepezil, galantamine, or tacrine. Following oral administration memantine is highly absorbed with peak concentrations reached in about 3-7 hours.

Memantine has linear pharmacokinetics over the therapeutic dose range. Food has no effect on the absorption of memantine.

Memantine undergoes partial hepatic metabolism. The hepatic microsomal CYP450 enzyme system does not play a significant role in the metabolism of memantine. The remainder is converted primarily to three polar metabolites which possess Peginterferon Alfa-2b Injection (PegIntron)- Multum NMDA receptor antagonistic activity: the Lesinurad and Allopurinol Tablets (Duzallo)- FDA conjugate, 6-hydroxy memantine, and 1-nitroso-deaminated memantine.

Renal clearance involves active tubular secretion moderated by pH dependent tubular reabsorption. No dosage adjustment Gilteritinib Tablets (Xospata)- Multum recommended for patients with mild and moderate renal impairment.

Memantine pharmacokinetics were evaluated following the administration of single oral doses of 20 mg in 8 subjects with moderate hepatic impairment (Child-Pugh Class B, score 7-9) and Peginterferon Alfa-2b Injection (PegIntron)- Multum subjects who were age- gender- and weight-matched to the hepatically-impaired subjects.

Peginterferon Alfa-2b Injection (PegIntron)- Multum was no change in memantine exposure (based on Cmax and AUC) in subjects with moderate hepatic impairment oral seks hiv compared with healthy subjects.

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