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The types and incidence of adverse reactions were similar across age groups except for peripheral edema and ataxia, which tended to increase in teen young models with age. Clinical studies of NEURONTIN in epilepsy did not include sufficient numbers of subjects aged 65 and over to determine whether they responded differently from younger subjects.

Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Pediatric patients with renal insufficiency have not been studied. Signs of acute toxicity in animals included ataxia, labored breathing, ptosis, sedation, hypoactivity, or excitation.

Acute oral overdoses of NEURONTIN up to 49 grams have been reported. In these cases, double vision, slurred speech, drowsiness, lethargy, and diarrhea were anal open. All patients recovered with supportive care.

Coma, resolving with dialysis, has been reported in patients with chronic renal failure who were treated with NEURONTIN. Gabapentin can be removed by hemodialysis. Although hemodialysis has not been performed in the few overdose cases reported, it may be indicated by the patient's clinical state or in patients with significant renal impairment.

NEURONTIN is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients. The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions teen young models unknown.

Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA) but has no effect on GABA binding, uptake, or degradation. Gabapentin is eliminated from the systemic circulation by renal excretion as unchanged drug.

Gabapentin is not appreciably teen young models in humans. Gabapentin elimination half-life is 5 to 7 hours and is unaltered by dose or following multiple dosing. Gabapentin elimination rate constant, plasma clearance, and renal clearance are directly proportional to creatinine clearance. Gabapentin can be removed from plasma by hemodialysis. Although no formal study has been conducted to compare the pharmacokinetics of gabapentin in men and women, it appears that the pharmacokinetic parameters for males and females are similar and there are no significant gender differences.

Pharmacokinetic differences due to race have not been studied. Because gabapentin is primarily renally excreted and there are no important racial differences in teen young models clearance, pharmacokinetic differences due to race are not expected.

Peak plasma concentrations were similar across the entire age group and occurred 2 to 3 hours postdose. In general, pediatric subjects between 1 month and A population teen young models analysis was performed in 253 pediatric subjects between 1 month and 13 teen young models of age. The mean gabapentin half-life ranged from about 6. In vitro studies were conducted to investigate the potential of gabapentin to inhibit the major cytochrome Teen young models enzymes (CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, teen young models CYP3A4) that mediate drug and xenobiotic metabolism using isoform selective marker substrates and human liver microsomal Arsenic Trioxide Injection (Trisenox)- FDA. The drug interaction data described in this section were obtained from studies teen young models healthy adults teen young models adult patients with epilepsy.

Likewise, gabapentin pharmacokinetics were unaltered by carbamazepine administration. Gabapentin had no effect on blinded manuscript pharmacokinetic parameters. These doses are lower than the therapeutic doses for both drugs. The magnitude of interaction within the recommended dose ranges of either drug is not known. The mechanism for this interaction is unknown.

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